League One Port Vale’s reward for beating Sunderland in the FA Cup is a quarter-final tie away to Chelsea, while Manchester City will host Liverpool in a heavyweight showdown.
Record 14-time winners Arsenal go to Southampton, eighth in the Championship.
Leeds United will travel to West Ham United, who beat Brentford on penalties after a 2-2 draw on Monday night.
Port Vale are the lowest ranked side left in the competition. It will be the first time they have met Chelsea in a competitive fixture since 1929.
The ties will be played across the weekend of 4-5 April.
FA Cup Quarter-Final Draw In Full
Southampton v Arsenal
Chelsea v Port Vale
Manchester City v Liverpool
West Ham United v Leeds United
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